As you might know, there is a 64-bit version of BizTalk 2006 R2. But there are some additional challanges when installing this version. I recently encountered strange errors when trying to configure the EDI/AS2 components. The solution was – hold on – to add the local network service account to the local admin group! The explanation seem to be that the configuration uses WMI scripts that are run under this account, and they need high permissions to run.